Human digestive physiology and evolutionary diet: a metabolomic perspective on carnivorous and scavenger adaptations

Vista sencilla de ítem
dc.contributor.authorClemente-Suárez, Vicente Javier
dc.contributor.authorRedondo-Flórez, Laura
dc.contributor.authorBeltrán-Velasco, Ana Isabel
dc.contributor.authorYáñez-Sepúlveda, Rodrigo
dc.contributor.authorRubio-Zarapuz, Alejandro
dc.contributor.authorMartín-Rodríguez, Alexandra
dc.contributor.authorNavarro-Jimenez, Eduardo
dc.contributor.authorTornero-Aguilera, José Francisco
dc.date.accessioned2025-09-23T22:08:48Z
dc.date.issued2025-07-04
dc.description.abstractThis review examines human digestive physiology and metabolic adaptations in the context of evolutionary dietary patterns, particularly those emphasizing carnivorous and scavenging behaviors. By integrating metabolomic data with archaeological, anatomical, and microbiological evidence, the study explores how early hominins adapted to intermittent but energy-dense animal-based diets. The analysis highlights the development of hepatic insulin resistance, enhanced fat and protein metabolism, and shifts in gut microbiota diversity as physiological signatures of meat consumption. Comparative evaluations of digestive enzyme profiles, intestinal morphology, and salivary composition underscore humans’ omnivorous flexibility and partial carnivorous specialization. Additionally, biomarkers such as ketone bodies, branched-chain amino acids, and trimethylamine-N-oxide are identified as metabolic indicators of habitual meat intake. These adaptations, though once evolutionarily advantageous, are discussed in relation to current metabolic disorders in modern nutritional contexts. Overall, this review presents a metabolomic framework for understanding the evolutionary trajectory of human digestion and its implications for health and dietary recommendations.en_EN
dc.formatapplication/pdf
dc.identifier.citationClemente-Suárez, V. J., Redondo-Flórez, L., Beltrán-Velasco, A. I., Yáñez-Sepúlveda, R., Rubio-Zarapuz, A., Martín-Rodríguez, A., Navarro-Jimenez, E., & Tornero-Aguilera, J. F. (2025). Human digestive physiology and evolutionary diet: a metabolomic perspective on carnivorous and scavenger adaptations. Metabolites, 15(7), 453. https://doi.org/10.3390/metabo15070453
dc.identifier.doihttps://doi.org/10.3390/metabo15070453
dc.identifier.urihttps://hdl.handle.net/20.500.12640/4630
dc.languageInglés
dc.language.isoeng
dc.publisherMDPI
dc.publisher.countryCH
dc.relation.ispartofurn:issn:2218-1989
dc.relation.urihttps://www.mdpi.com/2218-1989/15/7/453
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMetabolomicsen_EN
dc.subjectHuman dietary evolutionen_EN
dc.subjectMeat consumptionen_EN
dc.subjectDigestive adaptationen_EN
dc.subjectGut microbiotaen_EN
dc.subjectKetogenic metabolismen_EN
dc.subjectEnzyme evolutionen_EN
dc.subjectMetabolómicaes_ES
dc.subjectEvolución de la dieta humanaes_ES
dc.subjectConsumo de carnees_ES
dc.subjectAdaptación digestivaes_ES
dc.subjectMicrobiota intestinales_ES
dc.subjectMetabolismo cetogénicoes_ES
dc.subjectEvolución enzimáticaes_ES
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.03.00
dc.titleHuman digestive physiology and evolutionary diet: a metabolomic perspective on carnivorous and scavenger adaptationsen_EN
dc.typeinfo:eu-repo/semantics/article
dc.type.otherArtículo
dc.type.versioninfo:eu-repo/semantics/publishedVersion
local.acceso.esanAcceso abierto
local.author.orcidhttps://orcid.org/0000-0002-0747-8133
oaire.citation.issue7
oaire.citation.startPage453
oaire.citation.titleMetabolites
oaire.citation.volume15

Archivos

Bloque original

Mostrando 1 - 1 de 1
Miniatura
Nombre:
tornero_2025b.pdf
Tamaño:
655.8 KB
Formato:
Adobe Portable Document Format
Descripción:
Texto completo
Descargar

Colecciones

Artículos de revistas