Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)

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dc.contributor.authorArroyo-Acevedo, Jorge Luis
dc.contributor.authorHerrera-Calderon, Oscar
dc.contributor.authorTinco-Jayo, Johnny Aldo
dc.contributor.authorRojas-Armas, Juan Pedro
dc.contributor.authorRauf, Abdur
dc.contributor.authorHañari-Quispe, Renán
dc.contributor.authorFigueroa-Salvador, Linder
dc.contributor.authorFernández-Guzmán, Victor
dc.contributor.authorYuli-Posadas, Ricardo Ángel
dc.date.accessioned2023-01-23T02:17:23Z
dc.date.available2023-01-23T02:17:23Z
dc.date.issued2020-05-07
dc.description.abstractObjective: To determine the ameliorative effect of the ethanolic extract of Chuquiraga spinosa (ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. Methods: 36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. Results: Hematology showed that the triglyceride level was significantly lowered (P< 0.01) and high-density lipoprotein (HDL) level was significantly increased (P <0.01) in groups III, IV and V. Also, ChS extract significantly lowered the C reactive protein (CRP) level (P <0.01) and malondialdehyde level (P<0.05). There was a significant decrease in the frequency of DMBA-induced micronucleated polychromatic erythrocyte (P<0.01). Conclusions: Chuquiraga spinosa showed an ameliorative effect on DMBA-induced breast cancer in rats as well as antioxidant, antitumor and antigenotoxic properties.en_EN
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dc.identifier.citationArroyo-Acevedo, J. L., Herrera-Calderon, O., Tinco-Jayo, J. A., Rojas-Armas, J. P., Rauf, A., Hañari-Quispe, R., Figueroa-Salvador, L., Fernández-Guzmán, V., & Yuli-Posadas, R. A. (2020). Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA). Pharmacognosy Journal, 12(3), 562-568. https://doi.org/10.5530/pj.2020.12.85
dc.identifier.doihttps://doi.org/10.5530/pj.2020.12.85
dc.identifier.urihttps://hdl.handle.net/20.500.12640/3301
dc.language.isoeng
dc.publisherPharmacognosy Journal
dc.publisher.countryIN
dc.relation.ispartofurn:issn:0975-3575
dc.relation.urihttps://www.phcogj.com/sites/default/files/PharmacognJ-12-3-562.pdf
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectBreast tumoren_EN
dc.subjectPreventive medicineen_EN
dc.subjectPhytochemicalen_EN
dc.subjectAntioxidanten_EN
dc.subjectToxicityen_EN
dc.subjectAnticarcinogenic agenten_EN
dc.subjectTumor de mamaes_ES
dc.subjectMedicina preventivaes_ES
dc.subjectFitoquímicoes_ES
dc.subjectAntioxidantees_ES
dc.subjectToxicidades_ES
dc.subjectAgente anticancerígenoes_ES
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.01.05
dc.titleAmeliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)en_EN
dc.typeinfo:eu-repo/semantics/article
dc.type.otherArtículo
dc.type.versioninfo:eu-repo/semantics/publishedVersion
local.author.orcidhttps://orcid.org/0000-0003-3271-2523
oaire.citation.endPage568
oaire.citation.issue3
oaire.citation.startPage562
oaire.citation.titlePharmacognosy Journal
oaire.citation.volume12
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