Biomimetic strategies for nutraceutical delivery: advances in bionanomedicine for enhanced nutritional health

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dc.contributor.authorClemente-Suárez, Vicente Javier
dc.contributor.authorBustamante-Sanchez, Alvaro
dc.contributor.authorRubio-Zarapuz, Alejandro
dc.contributor.authorMartín-Rodríguez, Alexandra
dc.contributor.authorTornero-Aguilera, José Francisco
dc.contributor.authorBeltrán-Velasco, Ana Isabel
dc.date.accessioned2025-10-06T23:33:44Z
dc.date.issued2025-07-01
dc.description.abstractBackground: Biomimetic strategies have gained increasing attention for their ability to enhance the delivery, stability, and functionality of nutraceuticals by emulating natural biological systems. However, the literature remains fragmented, often focusing on isolated technologies without integrating regulatory, predictive, or translational perspectives. Objective: This review aims to provide a comprehensive and multidisciplinary synthesis of biomimetic and bio-inspired nanocarrier strategies for nutraceutical delivery, while identifying critical gaps in standardization, scalability, and clinical translation. Results: We present a structured classification matrix that maps biomimetic delivery systems by material type, target site, and bioactive compound class. In addition, we analyze predictive design tools (e.g., PBPK modeling and AI-based formulation), regulatory frameworks (e.g., EFSA, FDA, and GSRS), and risk-driven strategies as underexplored levers to accelerate innovation. The review also integrates ethical and environmental considerations, and highlights emerging trends such as multifunctional hybrid systems and green synthesis routes. Conclusions: By bridging scientific, technological, and regulatory domains, this review offers a novel conceptual and translational roadmap to guide the next generation of biomimetic nutraceutical delivery systems. It addresses key bottlenecks and proposes integrative strategies to enhance design precision, safety, and scalability.en_EN
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dc.identifier.citationClemente-Suárez, V. J., Bustamante-Sanchez, A., Rubio-Zarapuz, A., Martín-Rodríguez, A., Tornero-Aguilera, J. F., & Beltrán-Velasco, A. I. (2025). Biomimetic strategies for nutraceutical delivery: advances in bionanomedicine for enhanced nutritional health. Biomimetics, 10(7), 426. https://doi.org/10.3390/biomimetics10070426
dc.identifier.doihttps://doi.org/10.3390/biomimetics10070426
dc.identifier.urihttps://hdl.handle.net/20.500.12640/4634
dc.languageInglés
dc.language.isoeng
dc.publisherMDPI
dc.publisher.countryCH
dc.relation.ispartofurn:issn:2313-7673
dc.relation.urihttps://www.mdpi.com/2313-7673/10/7/426
dc.rightshttps://purl.org/coar/access_right/c_abf2
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBiomimetic deliveryen_EN
dc.subjectNutraceuticalsen_EN
dc.subjectBioavailability enhancementen_EN
dc.subjectAntioxidant nanocarriersen_EN
dc.subjectBiogenic nanoparticlesen_EN
dc.subjectTargeted nutrient deliveryen_EN
dc.subjectAdministración biomiméticaes_ES
dc.subjectNutracéuticoses_ES
dc.subjectMejora de la biodisponibilidades_ES
dc.subjectNanotransportadores antioxidanteses_ES
dc.subjectNanopartículas biogénicases_ES
dc.subjectAdministración dirigida de nutrienteses_ES
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.03.04
dc.titleBiomimetic strategies for nutraceutical delivery: advances in bionanomedicine for enhanced nutritional healthen_EN
dc.typehttps://purl.org/coar/resource_type/c_6501
dc.type.otherArtículo
dc.type.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
local.acceso.esanAcceso abierto
local.author.orcidhttps://orcid.org/0000-0002-0747-8133
oaire.citation.issue7
oaire.citation.startPage426
oaire.citation.titleBiomimetics
oaire.citation.volume10

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