Can a weekend of controlled hypoxia restore hormonal balance? A novel approach to stress recovery in aviation professionals

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dc.contributor.authorTornero-Aguilera, Jose Francisco
dc.contributor.authorMartin-Gomez, Francisco José
dc.contributor.authorMartinez-Taranilla, Manuel
dc.contributor.authorRubio-Zarapuz, Alejandro
dc.contributor.authorMartin-Rodríguez, Alexandra
dc.contributor.authorClemente-Suárez, Vicente Javier
dc.date.accessioned2025-09-23T22:08:48Z
dc.date.issued2025-06-25
dc.description.abstractBackground: Aviation professionals experience chronic stress due to prolonged work hours, irregular schedules, and exposure to altitude-related physiological challenges, leading to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. Controlled hypoxia has been proposed as a potential strategy for modulating stress responses and enhancing recovery. Objective: This study aimed to investigate the effects of a weekend of controlled normobaric hypoxia on key hormonal markers, including cortisol, prolactin, testosterone, and DHEA-S, in pilots and flight attendants. Methods: A within-subject experimental design was used with 10 participants (6 pilots, 4 flight attendants) exposed to two 12-hour sessions of normobaric hypoxia (simulated altitude: 3,500–4,000 m) during their designated rest period. Blood samples were collected at three-time points: baseline, pre-hypoxia, and post-hypoxia, and analyzed for hormonal changes. Results: Prolactin levels significantly increased post-intervention, indicating a neuroendocrine stress response. Cortisol levels showed a moderate decrease, suggesting potential stress adaptation. Testosterone levels significantly increased in both groups, supporting anabolic recovery mechanisms. DHEA-S exhibited a slight but non-significant increase, while the DHEA-S/cortisol ratio improved, suggesting enhanced stress resilience. Conclusion: Short-term exposure to normobaric hypoxia induced significant hormonal adaptations, potentially aiding stress recovery in aviation professionals. These findings highlight the potential of controlled hypoxia as a non-pharmacological intervention for stress management in high-demand professions. Further research is needed to refine hypoxia protocols and assess long-term effects.en_EN
dc.formatapplication/pdf
dc.identifier.citationTornero-Aguilera, J. F., Martin-Gomez, F. J., Martinez-Taranilla, M., Rubio-Zarapuz, A., Rodríguez, A. M., & Clemente-Suárez, V. J. (2025). Can a weekend of controlled hypoxia restore hormonal balance? A novel approach to stress recovery in aviation professionals. Frontiers in Physiology, 16, 1582591. https://doi.org/10.3389/fphys.2025.1582591
dc.identifier.doihttps://doi.org/10.3389/fphys.2025.1582591
dc.identifier.urihttps://hdl.handle.net/20.500.12640/4628
dc.languageInglés
dc.language.isoeng
dc.publisherFrontiers Media
dc.publisher.countryCH
dc.relation.ispartofurn:issn:1664-042X
dc.relation.urihttps://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1582591/full
dc.rightshttps://purl.org/coar/access_right/c_abf2
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNormobaric hypoxiaen_EN
dc.subjectStressen_EN
dc.subjectAviation professionalsen_EN
dc.subjectHPA axisen_EN
dc.subjectProlactinen_EN
dc.subjectCortisolen_EN
dc.subjectTestosteroneen_EN
dc.subjectDHEA-Sen_EN
dc.subjectHipoxia normobáricaes_ES
dc.subjectEstréses_ES
dc.subjectProfesionales de la aviaciónes_ES
dc.subjectEje HPAes_ES
dc.subjectProlactinaes_ES
dc.subjectCortisoles_ES
dc.subjectTestosteronaes_ES
dc.subjectDHEA-Ses_ES
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.01.08
dc.titleCan a weekend of controlled hypoxia restore hormonal balance? A novel approach to stress recovery in aviation professionalsen_EN
dc.typehttps://purl.org/coar/resource_type/c_6501
dc.type.otherArtículo
dc.type.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
local.acceso.esanAcceso abierto
local.author.orcidhttps://orcid.org/0000-0002-0747-8133
oaire.citation.startPage1582591
oaire.citation.titleFrontiers in Physiology
oaire.citation.volume16

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